Editor: Bogdian Czerniak, MD, PhD
Publisher: Elsevier – 1,506 pages
Book Review by: Nano Khilnani

The findings revealed in the second edition of this large book are partly from about 11,500 benign and malignant bone tumor cases handled by various doctors, around 8,400 malignant bone tumor cases of the National Cancer Institute, and some 9,500 consultation cases of Dr. Howard Dorfman, who is now retired but was co-editor of the first edition of this book that was published about 10 years ago.

This type of book in the area of skeletal pathology based on empirical data is rather rare. The work you are going to be reading is based on nearly 30,000 patients who had or have bone problems. In that respect there is no absolutely doubt or speculation surrounding these cases; they are all factual. And the variety of the cases you are going to be looking at in this massive book of over 1,500 pages is large, and its range, wide. To give you an overview, we provide you below the titles of the 24 chapters of this book:

  1. General Considerations
  2. Clinical Considerations and Imaging of Bone Tumors
  3. Molecular Biology of Bone Tumors
  4. Benign Osteoblastic Tumors
  5. Osteosarcoma
  6. Benign Cartilage Lesions
  7. Malignant Cartilage Tumors
  8. Fibrous Dysplasia and Related Lesions
  9. Fibrous and Fibrohistiocytic Lesions
  10. Giant Cell Lesions
  11. Ewing’s Sarcoma and Related Tumors
  12. Hematopoietic Tumors
  13. Vascular Lesions
  14. Neurogenous Tumors and Neurofibromatosis Affecting Bone
  15. Cystic Lesions
  16. Miscellaneous Mesenchymal Tumors
  17. Adamantinoma of Long Bone
  18. Chordoma and Related Lesions
  19. Metastatic Tumors in Bone
  20. Synovial Lesions
  21. Sclerosing Bone Lesions
  22. Tumor-Induced Osteomalacia and Rickets
  23. Reactive and Metabolic Conditions Simulating Neoplasms of Bone
  24. Precancerous Conditions

This book provides you the opportunity to not only look at a large range of situations but also to look at the various aspects of these cases, including their clinical, epidemiologic, molecular, and pathologic bases.

For your benefit, all the content of this printed book as outlined above can be viewed online by you, the purchaser. You can activate the eBook version of this title at no extra charge, and view it on the screen of almost any Internet-enabled device at anytime, and anywhere you are.

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And, you can get even more valuable information online from another useful allied website – www.ClinicalKey.com

This search engine of Elsevier Saunders is specially designed for doctors by providing them:

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In this book, you will find 24 chapters filled with a tremendous amount of information, but it is not overwhelming because of the very thoughtful and systematic way the information has been organized and presented for your use in each chapter by the editor Dr. Bogdan Czerniak.

As an example, let us go through what you will find in chapter 5 named Osteosarcoma on page 200. It begins, as all chapters do, with a highlighted box entitled Chapter Outline, and presentation and discussions of various topics related to this condition. This chapter is over 150 pages in length (p 200 – 355) and here is a broad-brush view of what is covered in it:

Chapter Outline

  • Intramedullary Osteosarcoma
  • Osteosarcoma Associated with Specific Clinical Syndromes
  • Secondary Osteosarcoma
  • Surface Osteosarcoma
  • Intracortical Osteosarcoma
  • Extraskeletal Osteosarcoma
  • References: a total of 443 reference materials, organized by type of osteosarcoma

This book contains a very large number of black-and-white and full-color images with detailed explanations in the photo captions of what is shown in them. It is a complete guide, perhaps as no other book, on bone pathology, on the clinical, epidemiologic, molecular, and pathologic aspects of tumors of the bone.  This is the definitive book on bone pathology.

Among the benefits of using this extensive volume are the following:

  • ExpertConsult eBook version included with purchase
  • Four brand-new chapters cover:
  1. Clinical Considerations and Imaging of Bone Tumors
  2. Hematopoietic Tumors
  3. Neurogenous Tumors and Neurofibromatosis Affecting Bone
  4. Metastatic Tumors in Bone
  • Information on molecular and genetic aspects of bone tumors
  • Comprehensive data from nearly 30,000 benign and malignant primary bone tumors, including 8,400 malignant bone tumors from the National Cancer Institute
  • Enhanced visual understanding with updated radiographic imaging and new, full-color high quality micrographs 
  • Updated molecular and epidemiologic diagrams added to all chapters


Bogdian Czerniak, MD, PhD is Professor of Pathology in the Department of Pathology at the University of Texas MD Anderson Cancer Center in Houston, Texas.

Howard D. Dorfman, MD is Professor Emeritus of Pathology, Orthopedic Surgery and Radiology at Albert Einstein College of Medicine of Yeshiva University in New York, New York.



Colleen M. Costellos, MD is Associate Professor of Radiology in the Department of Diagnostic Radiology at the University of Texas MD Anderson Cancer Center in Houston, Texas.

April Ewton, MD is Associate Professor of Pathology and Associate Medical Director of Hematopathology at Houston Methodist Hospital. She is also affiliated with the Department of Pathology and Genomic Medicine at Weill Cornell College of Cornell University in Houston, Texas.

Gregory N. Fuller, MD, PhD is Professor and Chief Neuropathologist in the Department of Pathology at the University of Texas MD Anderson Cancer Center in Houston, Texas.

John E. Madewell, MD is Professor and Chief of Musculoskeletal Imaging in the Department of Diagnostic Radiology at the University of Texas MD Anderson Cancer Center in Houston, Texas.

John D. Reith, MD is Professor Pathology in the Departments of Pathology, Immunology, Laboratory Medicine and Orthopedics and Rehabilitation at Shands Hospital at the University of Florida College of Medicine in Gainesville, Florida.