Authors: Henry C. Lim and Hwa Sung Shin
Publisher: Cambridge University Press – 457 pages
Book Review by: Sonu Chandiram

Since this book is about an industrial process we are not familiar with, we present here how this book is described by the editors as being different from others on the subject of fed-batch cultures, as follows:

“Most industrially important fermentation and bioreactor operations are carried out in fed-batch mode, producing a wide variety of products. This is the first book that puts together all the necessary background material regarding the “what, why, and how” of optimal and sub-optimal fed-batch operations. Numerous examples are provided to illustrate the application of optimal fed-batch cultures.”

“This unique book by experts with decades of research and industrial experience, is a must for researchers and industrial practitioners of fed-batch processes (modeling, control and operations) in the biotechnology, fermentation, food, pharmaceutical, and waste treatment industries.”

To provide you an overview of what is covered in it, we enumerate its 16 chapters below:

  1. Introduction to Fed-Batch Cultures
  2. Idealized reactors and Fed-Batch Reactors
  3. Maximization of Reaction Rates and Fed-Batch Operation
  4. Phenomena That Favor Fed-Batch Operations
  5. Classification and Characterization of Fed-Batch Cultures
  6. Models Based on Mass Balance Equations
  7. Non-Equation-Based Models
  8. Specific Rate Determination
  9. Optimization by Pontryagin’s Maximum Principle
  10. Computational Techniques
  11. Optimization of Single and Multiple Reactions
  12. Optimization for Cell Mass Production
  13. Optimization for Metabolite Production
  14. Simple Adaptive Optimization
  15. Measurements, Estimation, and Control
  16. Feasibility Assessment and Implementable Feed Rates

For those who want to learn about above-mentioned processes, we urge you to read this book.



Henry C. Lim gained industrial experience by working for five years for Pfizer in reaction engineering and separation and purification. He taught for 21 years at Purdue University and initiated biochemical research in 1970. He was recruited to the University of California in Irvine where he was founding chair for biochemical engineering and chemical engineering for 10 years and taught for 22 years.

He has extensive consulting experience with CJ Biotechnology, Eli Lilly, Leeds and Northrop, LG Biotech, Merck, Monsanto, Novo Enzyme Corporation, Pharmacontrol Inc. and Zander Renewable Systems. He has studied bio-reactions, bioreactor engineering, bioremediation, cellular regulation, control of bioreactors, modeling and optimization of bioreactors, and recombinant DNA technology.

Dr. Lim has supervised more than 50 PhD dissertations and has published two books and more than 160 journal articles. He has received a Food, Pharmaceutical and Bioengineering Division Award from the American Institute of Chemical Engineers (AIChe) for his work on bioreactor and enzyme engineering.

Hwa Sung Shin received formal education at Postech (Korea) and at the University of California in Irvine. After postdoctoral positions at UC Irvine and the University of Michigan, he joined the Department of Biological Engineering at Inha University. Dr. Shin studies the optimization and control of fed-batch fermentation, control of stem cells and neurons in microfluidic cell culture systems, and application of optimization theory to stem cells and neural tissues in defined macro- and microenvironments.