Author: Douglas C. Miller, MD
Publisher: Cambridge University Press–519 pages, with 1,200+ full-color photomicrographs
Book Review by: Nano Khilnani

The nervous system is the most complex organ system in the human body, and this may be reason why it is susceptible to large variety and range of diseases, Dr. Douglas Miller, the sole author of this highly informative text, states in his introductory note.

Much research in the field of neuropathology has been conducted in the past two decades, leading to better understanding of the causes of and treatment of diseases in the brain and within the vast network of nerves we all have.

This book was published in 2009, and just a decade earlier, brain tumors were an “automatic death sentence,” Dr. Miller writes. While much progress has been made in this medical specialty that has enabled the saving of more patients’ lives by neurosurgeons and neurologists, precision is a must in diagnosing neurologic disease.

“The pathologist plays an indispensable role in surgical diagnosis; he or she must accurately diagnose a potentially wide array of disease entities, determine the spread of disease within millimeters, and assess patient prognosis,” Dr. Miller cautions readers of this highly valuable book. Since neuroscience is such a precision-based field, we have laid out the entire contents of this book so that you won’t miss any part of any of the 44 chapters of this gem of a book:

  1. Introduction and Overview: Principles and Techniques
  2. Part I – Neoplasms
  3. Section I – Brain Neoplasms
  4. Subsection 1 – Intrinsic Brain Tumors
  5. Gliomas: An Overview
  6. Diffuse Fibrillary Astrocytomas
  7. Special Types of Astrocytomas
  8. Oligodendroglioma
  9. Mixed Gliomas
  10. Ependymomas
  11. Neuronal and Neuronal-Glial Tumors
  12. Primitive Neuroectodermal Tumors
  13. Primary CNS Lymphomas
  14. Primary CNS Germ Cell Neoplasms
  15. Hemangioblastoma
  16. Choroid Plexus Neoplasms and Miscellaneous Intracerebral Masses
  17. Metastatic Neoplasms in the Brain Parenchyma
  18. Subsection 2 – Extrinsic Brain Tumors
  19. Meningiomas
  20. Nonmeningioma Dural-Based Neoplasms
  21. Dura and Leptomeningeal Metastatic Cancer
  22. Tumors of Intracranial Peripheral Nerves
  23. Craniopharyngioma and Rathke’s Cleft Cysts
  24. Miscellaneous Meningeal Masses
  25. Pituitary Tumors
  26. Skull-Based Neoplasms
  27. Section 2 – Spinal Cord Neoplasms
  28. Subsection 1 – Intrinsic Spinal Cord Tumors
  29. Intrinsic Spinal Cord Tumors, I: Overview
  30. Ependymomas of the Spinal Cord
  31. Other Gliomas of the Spinal Cord
  32. Miscellaneous Cord Tumors
  33. Subsection 2 – Extrinsic Spinal Cord Neoplasms
  34. Meningiomas and Other Primary Dural-Based Tumors of the Spinal Cord
  35. Nerve Root Tumors
  36. Tumors of the Spine
  37. Part II – Nonneoplastic Mass Lesions
  38. Tumefactive Demyelinating Disease: Its Surgical Pathology and Differential Diagnosis
  39. Inflammatory Masses in the Brain Parenchyma
  40. Extraaxial Inflammatory / Infectious Lesions
  41. Biopsies of the Cerebral Infarcts
  42. Extraaxial Intracranial Hemorrhages
  43. Malformations of or in the CNS Parenchyma
  44. Part III – Diagnostic Brain Biopsies for Non-Neoplastic Disease
  45. Biopsies for Vasculitis
  46. Biopsies with / for Noninflammatory Vascular Diseases
  47. Biopsies for Diagnosis of Dementia
  48. Biopsies for Infectious Diseases
  49. Part IV – Surgical Neuropathology of Epilepsy
  50. Current Procedures Leading to Epilepsy Surgery: What the Neuropathologist Should Know about the Epilepsy Workup Prior to Surgery
  51. Abnormalities Probably Causing Epilepsy
  52. Effects of Epilepsy Manifest in Re-sected Brain Tissue
  53. Iatrogenic Lesions
  54. Special Syndromes and Epilepsy

This is a highly detailed and useful book for anyone aspiring to enter the field of neuropathology, and for established practitioners as well.



Douglas C. Miller, MD, PhD is Clinical Professor in Pathology and Anatomical Sciences at the University of Missouri School of Medicine in Columbia, Missouri. Previously Dr. Miller was Professor of Neuropathology and Neurosurgery at New York University Medical Center, where he was also Director of Neuropathology